Maximum score: 100%
Minimum score: 48%
Approximate scale:
100 - 89 = A
88 - 76 = B
75 - 59 = C
58 - 52 = D
51 - 48 = F
| Average score: 72% Maximum score: 100% Minimum score: 48% Approximate scale: 100 - 89 = A 88 - 76 = B 75 - 59 = C 58 - 52 = D 51 - 48 = F |
|
Questions numbered 1 through 25 count 2 points each (50 points).
| A | 1. | (1) | The adenylate cyclase activity of the Bacillus anthracis edema factor toxin. |
| (2) | The adenylate cyclase activity of the Bacillus anthracis lethal factor toxin. | ||
| B | 2. | (1) | The role of altered receptors in the mechanism of chloramphenicol resistance. |
| (2) | The role of altered receptors in the mechanism of streptomycin resistance. | ||
| A | 3. | (1) | The importance of an animal reservoir in the transmission of Salmonella to humans. |
| (2) | The importance of an animal reservoir in the transmission of Shigella to humans. | ||
| A | 4. | (1) | The probability that an acute infection involving Group A streptococci may progress to glomerulonephritis. |
| (2) | The probability that an acute infection involving Group D streptococci may progress to glomerulonephritis. | ||
| B | 5. | (1) | The role of anti-capsular antibodies in host defense against S. pyogenes. |
| (2) | The role of anti-capsular antibodies in host defense against S. pneumoniae. | ||
| B | 6. | (1) | The ability of beta-lactam antibiotics to inhibit bacterial protein synthesis. |
| (2) | The ability of macrolide antibiotics to inhibit bacterial protein synthesis. | ||
| B | 7. | (1) | The average time between ingestion and the onset of symptoms for the vomiting form of Bacillus cereus food poisoning. |
| (2) | The average time between ingestion and the onset of symptoms for the diarrheal form of Bacillus cereus food poisoning. | ||
| A | 8. | (1) | The frequency of community-acquired urinary tract infections that are due to E. coli. |
| (2) | The frequency of community-acquired urinary tract infections that are due to Proteus. | ||
| A | 9. | (1) | The level of crosslinking in the peptidoglycan from a Gram-positive cell. |
| (2) | The level of crosslinking in the peptidoglycan from a Gram-negative cell. | ||
| C | 10. | (1) | The role of crowded, unsanitary conditions in the transmission of dysentery. |
| (2) | The role of crowded, unsanitary conditions in the transmission of cholera. | ||
| B | 11. | (1) | The number of different H-antigens that have been observed in the genus Klebsiella. |
| (2) | The number of different H-antigens that have been observed in the genus Escherichia. | ||
| B | 12. | (1) | The ability to differentiate different species of Staphylococcus by testing for the presence of the enzyme catalase. |
| (2) | The ability to differentiate different species of Staphylococcus by testing for the presence of the enzyme coagulase. | ||
| A | 13. | (1) | The role of fleas in the transmission of Yersinia pestis. |
| (2) | The role of ticks in the transmission of Yersinia pestis. | ||
| B | 14. | (1) | The role of humoral defenses in preventing disease due to Brucella. |
| (2) | The role of cell-mediated defenses in preventing disease due to Brucella. | ||
| A | 15. | (1) | The ability of Staphylococcus protein A to bind the Fc portion of IgG. |
| (2) | The ability of Streptococcus M protein to bind the Fc portion of IgG. | ||
| A | 16. | (1) | The frequency of isolation of Bacteroides from various anaerobic infections. |
| (2) | The frequency of isolation of Bacillus from various anaerobic infections. | ||
| A | 17. | (1) | The occurrence of meningitis that is due to Haemophilus influenzae in very young children. |
| (2) | The occurrence of meningitis that is due to Haemophilus influenzae in adults. | ||
| A | 18. | (1) | The ability of piliated strains of Neisseria gonorrhoeae to produce disease. |
| (2) | The ability of non-piliated strains of Neisseria gonorrhoeae to produce disease. | ||
| B | 19. | (1) | The role of SLT cytotoxins in the pathogenesis of enterotoxigenic strains of E. coli. |
| (2) | The role of SLT cytotoxins in the pathogenesis of enterohemorrhagic strains of E. coli. | ||
| A | 20. | (1) | The number of strains of S. aureus that contain protein A in the cell wall. |
| (2) | The number of strains of S. pyogenes that contain protein A in the cell wall. | ||
| A | 21. | (1) | The ability of tetanus toxin to block the release of the neurotransmitter glycine. |
| (2) | The ability of botulism toxin to block the release of the neurotransmitter glycine. | ||
| B | 22. | (1) | The length of the incubation period for gastroenteritis produced by Salmonella enteritidis. |
| (2) | The length of the incubation period for typhoid fever produced by Salmonella typhi. | ||
| A | 23. | (1) | The percentage of the oral cavity normal flora that are represented by the genus Streptococcus. |
| (2) | The percentage of the oral cavity normal flora that are represented by the genus Staphylococcus. | ||
| B | 24. | (1) | The ability of Vibrio cholerae to tolerate acidic conditions. |
| (2) | The ability of Vibrio cholerae to tolerate alkaline conditions. | ||
| B | 25. | (1) | The occurrence of the characteristic spasmatic cough during the catarrhal phase of pertussis. |
| (2) | The occurrence of the characteristic spasmatic cough during the paroxysmal phase of pertussis. |
| Questions 26-28. Indicate the MOST IMPORTANT CELL SURFACE COMPONENT listed on the right for each of the ORGANISMS listed on the left. Each lettered choice may be used once, more than once or not at all. | |||||
| C | 26. | Neisseria gonorrhoeae | A. | Protein A | |
| D | 27. | Yersinia pestis | B. | M Protein | |
| B | 28. | Streptococcus pyogenes | C. | Protein I | |
| D. | VW Antigen | ||||
| E. | All of the above | ||||
| F. | None of the above | ||||
Questions 29-31. Indicate the SITE OF ACTIVITY listed on the right for each of the ANTIBIOTICS listed on the left. Each lettered choice may be used once, more than once or not at all. | |||||
| E | 29. | Nalidixic acid | A. | Integrity of the cell wall | |
| D | 30. | Erythromycin | B. | Synthesis of the cell wall | |
| A | 31. | Lysozyme | C. | Integrity of proteins | |
| D. | Synthesis of proteins | ||||
| E. | Synthesis of nucleic acids | ||||
| F. | None of the above | ||||
Questions 32-35. Indicate the MOST IMPORTANT VIRULENCE FACTOR listed on the right for each of the ORGANISMS listed on the left. Each lettered choice may be used once, more than once or not at all. | |||||
| D | 32. | Vibrio cholerae | A. | Intracellular growth | |
| D | 33. | Bacillus cereus | B. | Anti-phagocytic capsule | |
| A | 34. | Brucella canis | C. | Invasion of tissues | |
| C | 35. | Shigella dysenteriae | D. | Production of toxins | |
| E. | All of the above | ||||
| F. | None of the above | ||||
Questions 36-38. Indicate the MOST IMPORTANT HOST DEFENSE MECHANISM listed on the right for each of the DISEASES listed on the left. Each lettered choice may be used once, more than once or not at all. | |||||
| B | 36. | Plague | A. | Normal flora | |
| C | 37. | Whooping cough | B. | Opsonizing antibodies | |
| C | 38. | Cholera | C. | Anti-toxin antibodies | |
| D. | Cell-mediated response | ||||
| E. | All of the above | ||||
| F. | None of the above | ||||
| A. Bacillus anthracis | B. Bacteroides fragilis | C. Bordetella pertussis |
| D. Brucella abortus | E. Campylobacter jejuni | F. Clostridium perfringens |
| G. Clostridium tetani | H. Escherichia coli | I. Haemophilus influenzae |
| J. Neisseria meningitidis | K. Pseudomonas | L. Salmonella enteritidis |
| M. Shigella dysenteriae | N. Staphylococcus aureus | O. Streptococcus pneumoniae |
| P. Streptococcus pyogenes | R. Vibrio cholerae | S. Yersinia pestis |
| K | 39. | i) patient is a fireman who was severely burned, ii) despite topical antibiotic therapy, the wounds became infected, iii) greenish-pigmented Gram-negative rods were isolated from the wounds. |
| N | 40. | i) patient is an SIU student, ii) patient complains of vomiting, diarrhea and abdominal pain about 4 hours following ingestion of an "old" ham sandwich, iii) the patient recovered completely in about 24 hours and no pathogenic bacteria were cultured from the feces. |
| O | 41. | i) patient is an elderly man who recently had influenza, ii) patient now reports to the emergency room with severe chills and a productive cough, iii) catalase-negative, Gram positive cocci are isolated from the patient's sputum. |
| I | 42. | i) patient is a small child attending day care, ii) patient presents with a high fever, iii) Gram-negative coccobacilli are observed in a smear of cerebrospinal fluid. |
| A | 43. | i) patient is a goat farmer, ii) patient presents with a small, black, necrotic lesion on the forearm, iii) Gram-positive rods are observed in smear of the lesion material. |
| H | 44. | i) patient is a 47-year old man who is in the hospital for a routine surgical procedure, ii) patient suddenly develops a high fever, iii) Gram-negative bacteria that ferment lactose are isolated from the patient's blood. |
| L | 45. | i) patient is a 32-year old woman, ii) patient reports having nausea, vomiting and diarrhea about 2 days after eating some poorly cooked chicken, iii) Gram-negative, hydrogen sulfide-producing bacteria were isolated from the feces. |
| B | 46. | i) patient is a 62-year old man, ii) patient reports to the emergency room with a high fever and abdominal tenderness, iii) surgery reveals a ruptured appendix and intra-abdominal infection having a very foul odor. |
| BONUS QUESTION: | ||
| 47. | What is the name of the antibiotic shown in the figure to the right? (3 points) | |
| Tetracycline |  | |